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The Wu Lab
Genome duplication is a critical part of the cell cycle that is highly regulated to ensure proper cell growth and proliferation. The distribution of the sites of initiation of DNA replication, or origins, across the genome changes during development and differentiation, suggesting that the program of genome duplication is highly controlled. Alterations in the replication pattern have also been observed in a number of pathologies, such as in cancers. However, the fundamental features driving origin selection and the importance of using specific replication programs remain surprisingly unknown. The research in our laboratory aims to study different aspects of genome duplication and maintenance using the fission yeast Schizosaccharomyces pombe as a model system.
The organization of genome duplication is a critical determinant of the landscape of genome maintenance Gomez-Escoda B and Wu PY Genome Research 28:1179-1192 (August 2018) Abstract   Download PDF |
CDK activity provides temporal and quantitative cues for organizing genome duplication Perrot A, Millington CL, Gomez-Escoda B, Schausi-Tiffoche D, and Wu PY PLOS Genetics 14(2):e1007214 (February 2018) Abstract   Download PDF |